BRAND CORE TECH.
Clinic solutions beyond cosmetics
The value of [PR]4 lies in its technical expertise..
[PR]4 studies ECM (extracellular matrix) of the skin and continues with research and development of the optimal, cosmetic formulation and composition to provide professional MeD Solution for medical skin concerns
Intensive care with H.ECMTM for fast skin recovery
The pace at which skin damage is repaired depends on the working of the epidermal extracellular matrix (ECM). H∙ECM™ of [PR]4 is an original ingredient that combines *proteoglycan linked to hyaluronic acid and collagen using the liposome technology to help with skin regeneration and restore a strong skin structure.
Ingredient name: H.ECM™ liposome / Ingredient application no.: 10-2019-0122088 / Name of invention: Cosmetic composition for skin moisturizing and the manufacturing method thereof
By processing [PR]4’s exclusive patented ingredient of H.ECM™ into liposome, recovery and regeneration effect for skin damaged by laser treatment is maximized.
Excellent skin improvement effect of H.ECM™ liposome, verified through clinical trials
H.ECM™ liposome In-vitro test
H.ECM™ liposome helps with skin barrier (filaggrin), moisturizing (HAS3, AQP3), anti-wrinkle (COL1A1, MMP1), anti-glycation and anti-inflammation care

In particular, the expression of cell’s moisture path aquaporin (AQP3) and collagen cell (COL1A1) far exceed the positive control group of EGF.
* Ref : TNF-α(RAW264.7)/Filaggrin, HAS3, AQP3(Human Epidermal Keratinocyte)/COL1A1,
MMP1 (Human Dermal Fibroblast) In-vitro test in GMRC-19813-V1, Seoul. 20190808~0924

* Test : In-vitro test on H.ECM™ liposome factors related to anti-glycation,
anti-inflammation, skin barrier, skin moisturizing and skin wrinkle / Test Agency : Global Medical Research Center / Period : August 8, 2019 - September 27, 2019